Detroit Lions vs. Buffalo Bills Prediction

The Play

The official NFL play for Detroit Lions vs. Buffalo Bills on September 17, 2026 was Buffalo Bills ML (-228) (moneyline), sized at 1.5u.

Every official play is logged here at the price it was sent and graded against the final score.

Result

The NFL pick on Detroit Lions vs. Buffalo Bills graded as a WIN for +1.50u.

This Game

Opening and closing lines, line movement and the final score: Detroit Lions vs. Buffalo Bills game page.

About This Archive

Every Gridiron & Wine NFL official play is logged and published — wins, losses, and pushes alike. No deletions. The full track record is verified here, and every graded play is in the NFL pick archive.

More on our NFL plays on the NFL picks page, or see the glossary for any unfamiliar terms.